Ramirez

Instructions for Rotary Evaporator _ Vacuum _ Instrument _ Condenser

Original title Instructions for Use of Rotary Evaporator Rotary evaporator is mainly used for concentration crystallization drying separation and solvent recovery in pharmaceutical chemical and biopharmaceutical industries The principle is as follows under the vacuum condition the rotating bottle is heated at a constant temperature so that the rotating bottle rotates at a constant speed and the material forms a large-area film on the bottle wall and is evaporated efficiently The solvent vapor is cooled by a high-efficiency glass condenser and recovered in a collecting bottle thereby greatly improving the evaporation efficiency It is especially suitable for the concentration and purification of biological products which are easy to decompose and denature at high temperature rotovap distillation The rotary evaporator of our company has formed 2L 3L 5L 10L 20L and 50L series by collecting the essence of similar products at home and abroad and accumulating the successful practical experience of our company The product design follows the principles of high efficiency practicality and economy All for the sake of users Features of R-3001 rotary evaporator 1 Variable frequency speed regulation imported frequency converter stable and reliable operation 2 the use of polytetrafluoroethylene and rubber composite seal can maintain a high degree of vacuum 3 Adopt high-efficiency condenser to ensure high recovery rate And 4 that rotate bottle is connected by a nut and is convenient to assemble and disassemble Expand the full text And 5 a piston is arrange at that lower open of the collecting bottle so that the solvent can be recovered very quickly And 6 continuous feed is available 7 The vacuum system is equipped with a vacuum meter which can select the best working vacuum degree for low boiling point materials 8 The water bath pot is controlled by digital constant temperature and can be lifted up and down 9 Reasonable structure and exquisite materials A large number of stainless steel and aluminum alloy parts are used in mechanical structure All glass rooms are made of high temperature resistant glass Rubber seal wearing parts all adopt the new national standard which is convenient for users to purchase and replace Installation of rotary evaporator 1 Place the rack near the water source and firmly on the workbench In case of unevenness four rubber feet can be placed 2 Install the upright rod of the electric cabinet and the electric cabinet on the rack tighten the fixing nut thread and connect the coreless plug of the motor 3 Install the fixing clip of the condenser on the vertical rod of the vacuum meter and then install the vertical rod of the vacuum meter on the rack and fix it 4 Install the gas guide bottle on the machine head 5 Connect the secondary condenser with the gas guide bottle support it with a bracket and install a special PTFE gasket at the connection 6 Connect the collecting bottle with the secondary condenser hold it with a bracket and install a special PTFE gasket at the connection 7 Insert the main condenser on the auxiliary condenser and fix it with the fixing clip 8 Installation extraction port feed valve and discharge valve 9 Install the rotating bottle on the machine head and press the locking button on the machine head to lock the rotating bottle 10 Place the water bath pot under the rotating bottle and add water to 2/3 of the pot Adjust the water bath height 11 Connect the joint above the vacuum meter with a vacuum hose at the exhaust pipe and connect the other joint to the vacuum pump 12 Connect the cooling water and feeding pipe Precautions for rotary evaporator 1 All glass parts shall be cleaned before installation 2 Apply a small amount of vacuum silicone grease on each standard port and sealing surface to increase the airtightness 3 Be sure to lock the bottle mouth bracket and machine head before the instrument works 4 Do not move the whole machine Application method of rotary evaporator The evaporation rate of the instrument depends on three conditions 1 The better the vacuum degree is rotary vacuum evaporator the faster the speed is The vacuum degree shall not be less than 0096 MPa during water evaporation 2 The higher the water bath temperature the faster the speed generally not more than 80 degrees according to the specific process requirements 3 The lower the cooling water temperature is the faster the speed is and the better the refrigeration effect is (I) Operating procedures 1 Vacuumize After turning on the vacuum pump check whether the bottle mouth is sealed whether the vacuum pump itself leaks and whether the sealing ring at the rotating shaft is intact Connect a vacuum switch in the external vacuum tube to fine-tune the best recovery rate and evaporation rate 2 Feeding By using the vacuum negative pressure of the system the liquid material can be added to the material port and sucked into the rotating bottle with a hose The liquid material should not exceed half of the rotating bottle The instrument can be used for continuous feeding Attention shall be paid during feeding turn off the vacuum pump stop heating and slowly open the cock of the feeding pipe after the evaporation stops to prevent backflow 3 Heating The instrument is equipped with a specially designed water bath which must be powered on after heating The temperature control scale is 0-90 degrees for reference Due to the existence of thermal inertia the actual water temperature is about 2 degrees higher than wiped film distillation the set temperature The set value can be corrected when using If you need a water temperature of 40 degrees you can set the temperature controller to 38 degrees Please use a thermometer to measure the precise water temperature directly Rotate flat into water 1/3 — 1/2

Unplug the power plug with a plug 4 Rotation Turn on the switch of the electric cabinet adjust the knob to the best evaporation speed and pay attention to avoid the fluctuation of water bath vibration 5 Connect the cooling water 6 Recycle the solvent turn off the vacuum pump turn on the feeding switch to release the gas and open the discharge piston to discharge the solvent in the collection bottle (II) Precautions 1 About vacuum degree Vacuum degree is the most important process parameter of rotary evaporator but users often encounter the problem that the vacuum degree can not be reached This is often related to the nature of the solvent used Biochemical and pharmaceutical industries often use water ethanol acetone acetic acid ether petroleum ether chloroform toluene and other solvents However the general vacuum pump can not resist strong organic solvents so the special vacuum pump with strong corrosion resistance can be used (It is recommended to use water circulation vacuum pump which is available in our company) A simple way to check whet that instrument is leaking is to clip off the external vacuum hose and observe whet the vacuum gauge on the instrument can be kept for five minutes If there is air leakage check whether the sealing ring on each sealing joint and rotating shaft is effective (see maintenance) On the contrary if the instrument is normal the vacuum pump and vacuum pipeline should be checked 2 About motor temperature rise The motor of this instrument is a three-phase 220V special motor with E-class insulation The winding is made of polyester high-strength enameled wire The operating environment and altitude are not more than 1000 meters and the ambient temperature is not more than 40 degrees It is normal that the surface temperature of the motor (the difference between the surface temperature of the motor and the environment) does not exceed 45 degrees If the temperature rise exceeds 45 degrees check the relevant transmission lubrication system V Maintenance 1 Glass parts In case of serious dirt dilute sulfuric acid can be used for cleaning 2 Seal ring frequently check the wear degree of the seal ring and replace the worn seal ring in time to ensure the vacuum degree 3 Teflon interface In general it is not necessary to disassemble and wash If there is serious dirt it can be disassembled and washed 4 Water bath; if tap water is used Regularly clean the water stains on the electric heating coil To ensure good heating Return to Sohu to see more Responsible Editor toptiontech.com

Application of Rectification Technology in Chemical Plant Introduction _ Process

Original Title Introduction to Application of Distillation Technology in Chemical Plant Introduction In the production of pharmacy and fine chemical industry there are often many liquid phase or vapor phase mixtures that need to be separated or purified Distillation technology has become the most widely used and largest mass transfer separation process Today I will tell you about the types of distillation and illustrate the process flow in actual production Distillation technology is a process in which the mixture is separated by multiple partial vaporization and multiple partial condensation under a certain pressure so as to obtain the part close to the pure state The distillation process in industrial production is a process in which the partial gasification thin film distillation process and the partial condensation process are organically combined in the distillation column The distillation operation is divided into continuous operation and batch operation and the equipment used is similar It mainly comprises a rectifying tower a condenser and a reboiler The column equipment used for rectification includes plate column and packed column and the plate column is commonly used Classification of distillation technology and examples of process flow in actual production Expand the full text Additive rectification The rectification method achieves the separation effect by adding a certain component (called entrainer) to form an azeotrope with one or more components in the separated system or destroy the azeotrope that may exist between the components of the original material which can be divided into extractive rectification azeotropic rectification and salt-adding rectification Azeotropic distillation Azeotropic distillation is a process of separation by using the property that substances in a mixture can form azeotropes Azeotropic distillation is the distillation of multicomponent (at least three components) non-ideal solutions According to whether the azeotrope can be separated into two immiscible liquid phases it can be divided into homogeneous azeotropic distillation and heterogeneous azeotropic distillation Process with heterogeneous azeotrope as overhead product Adding ethanol-water azeotropic mixture and entrainer benzene into tower a to obtain pure ethanol at the bottom of the tower A ternary azeotropic mixture of water ethanol and benzene is obtained at the top of the tower and enters a phase separator after being condensed to form two liquid layers in the phase separator wherein the upper layer is rich in benzene and the lower layer is rich in ethanol The benzene-rich layer flows back to the tower a to supplement entrainer the ethanol-rich layer enters the tower B the benzene-ethanol azeotrope is obtained at the top of the tower to recover benzene and the mixture of ethanol and water obtained at the bottom of the tower enters the tower C The top of tower C is ethanol-water azeotrope and the bottom of tower C is pure water Through this process the separation of ethanol and water can be completed Process in which the product at the top of the column is a homogeneous azeotrope This kind of azeotropic distillation process is more complex Figure 19 shows a process for the separation of toluene from alkanes near boiling points using methanol as an entrainer The product (methanol-alkane azeotrope) at the top of the tower a is not layered after condensation and the recovery of the entrainer cannot use a simple layering method and the product at the top of the tower a needs to be introduced into the extraction tower B and water is added from the top to extract toluene The light-phase alkane is obtained from the top of the extraction tower and the methanol-water solution from the bottom can be separated into methanol and water in a common rectification tower The product at the bottom of tower a enters into tower D toluene is obtained at the bottom of tower D and the product at the top of tower a is partially refluxed and partially returned to tower a for further use Extractive distillation Extractive distillation is a process in which an extractant (a third component) is added to the component to be separated to significantly change the relative volatility of the component to be separated In the benzene refining process the benzene product after coking pretreatment is introduced into the stage of removing alkane and olefin by extractive distillation as shown in Figure 2-2 the pretreated raw material is added into the middle part of the extractive distillation tower the extractant is added from the top of the extractive distillation tower and the saturated solvent (mainly including extractant benzene and thiophene) is discharged from the bottom of the tower A raffinate (a mixture containing more impurities) is withdrawn from the top of the column Then the saturated solvent is sent to a solvent recovery tower for solvent recovery and the recovered solvent is sent to the top of an extraction tower and a rectification tower for recycling Salted extractive distillation Salt-adding extractive distillation is a separation process that uses solid salt as extractant or adds solid salt to extractant to improve the separation performance of extractant

The feed (methanol-toluene azeotrope) enters from the bottom of the extraction tower (T1) after being mixed with the near-boiling mixture of methanol and toluene distilled from the top of the toluene recovery tower (T2) The salt-added extractant returned from the bottom of the methanol recovery tower (T3) is cooled to 35 ℃ by the cooler (E5) and then enters the top of the T1 tower to complete countercurrent extraction in the T1 tower winterization filtration The raffinate phase at the top of the T1 tower enters the toluene recovery tower (T2) the qualified toluene product is obtained at the bottom of the tower and the material at the top of the tower returns to the bottom of the T1 tower The extract phase at the bottom of tower T1 enters the methanol recovery tower (T3) and the qualified methanol product is obtained at the top of the tower The saline at the bottom of the tower returns to the top of tower T1 after cooling Composite (or coupled) distillation Compound distillation is to couple various distillation forms to achieve the purpose of strengthening the mass transfer process and simplifying the process Typical examples include reactive distillation adsorptive distillation crystallization distillation and membrane distillation Reactive distillation Reactive distillation is a coupling process in which the reaction process and distillation separation are organically combined in the same equipment Reactive distillation is only applicable to the process in which chemical reaction and distillation are carried out in the same temperature and pressure range A typical liquid phase reversible reaction a + B BC + D at normal temperature and pressure is taken as an example to introduce the process flow of reactive distillation The order of volatility of a B C and D is C a B and D and the target product is D It can be seen from Figure (B) that by using the reactive distillation technology the raw materials A and B enter the reactive distillation column from the lower and upper parts of the reaction section respectively and fully contact and react in the reaction section so that the target product and reactant are separated in time Adsorption distillation Adsorptive distillation is a new type of intensified distillation process which combines the advantages of high separation factor high product purity and low energy consumption with the advantages of continuous production and large processing capacity of distillation Process flow diagram 1-6 shows the process of adsorption distillation separation of tert-butyl alcohol-water azeotrope by using the slurry composed of ethylene glycol as carrier liquid and 4A molecular sieve as adsorbent The dilute tert-butyl alcohol aqueous solution is continuously input to the lower part of the adsorption distillation tower and simultaneously a certain amount of slurry formed by the ethylene glycol and the 4A molecular sieve is continuously input from the upper part of the adsorption distillation tower Because the boiling point of ethylene glycol is higher than that of water and the boiling point of water is higher than that of tert-butyl alcohol in the adsorption distillation tower the tert-butyl alcohol is enriched to the top of the tower due to distillation and adsorption of 4A molecular sieve and at the same time the slurry formed by water ethylene glycol and 4A molecular sieve flows to the bottom of the tower at the same time part of water remains in the carrier liquid and the other part is adsorbed by 4A molecular sieve The tower bottom liquid of the adsorption distillation tower is then sent to the distillation desorption tower Due to the distillation effect and the desorption effect of the 4A molecular sieve water is enriched at the top of the distillation desorption tower At the same time the water in the 4A molecular sieve is desorbed The slurry composed of the glycol carrier liquid and 4A molecular sieve flows to the tower bottom and finally flows back to the adsorption distillation tower for further use molecular distillation systems Crystallization and rectification Crystallization and distillation is a process that combines crystallization and distillation which can not only obtain high-purity products but also strengthen the distillation process The crystallization rectification is used for separating isomers of MDI and the MDI has three isomers of 24 '-MDI44' -MDI and 22 '-MDI wherein the MDI-100 refers to the MDI containing 44' -MDI with the purity of more than 99% and the MDI-50 refers to 24 '-MDI and 4 4 '-MDI In that proces the material firstly enters a melting crystallize and the crystallizer adopts a suspension crystallization mode to partially crystallize the 4 4 '-MDI After separation the crystal is washed for many times to be the MDI-100 product and the washing liquid is refluxed to the crystallizer for recrystallization The mother liquor is heated and then enters a vacuum rectification device and the reflux ratio and the extraction amount at the top of the tower are controlled so that the mass fraction of 2 4 '-MDI in a 2 4' -MDI side-line extraction outlet is about 50% and the 2 4-MDI is used as an MDI-50 product

The 2 4 '-MDI content in the 4 4' -MDI side outlet is 10% which is used as reflux to mix with the feed and then enter the crystallizer for recrystallization Distillation under Unconventional Conditions Unconventional condition is a relative concept Compared with the general distillation process the distillation under unconventional conditions means that the operating parameters (such as operating temperature pressure etc) are carried out under more extreme conditions or the quality (purity) of the separation object or the obtained product is required to be very high Molecular distillation Principle of molecular distillation Different molecules have different effective molecular diameters so their mean free paths are also different Molecular distillation technology is based on the difference of mean free path of different substance molecules after they are heated and evaporated from the liquid surface to achieve separation and purification The specific method comprises the following steps of arranging a condensation surface above the liquid surface wherein the condensation surface is larger than the mean free path of heavy molecules and smaller than the mean free path of light molecules so that the heavy molecules cannot reach the condensation surface and return to the liquid surface to keep the original balance; and continuously condensing the light molecules on the condensation surfaces As a result the dynamic balance of light molecules is destroyed and the light molecules in the mixed liquid continuously escape from the liquid phase and finally the purpose of separation is achieved The specific process (see figure below) Vacuum rectification Vacuum distillation refers to the operation of distillation process under vacuum which is often used for the separation and purification of high boiling point substances or heat-sensitive substances Vacuum distillation process is widely used in the production of fine chemicals The selenium residue containing impurities is distilled twice to finally obtain selenium with higher purity SUNCHEM It has been focusing on the R & D production and sales of hydrogenation catalysts for 15 years and is positioned to provide users with the most suitable special catalyst products mainly serving the pharmaceutical pesticide dye spice chemical and other industries Xunkai's special catalyst products have been applied to the hydrogenation dehydrogenation reductive amination desulfurization and other processes in the fields of sorbitol BDO caprolactam fatty alcohol polyether amine butanol and octanol HPPO petroleum resin hydrogenation RT base alcohol hydrofining and so on Xunkai is striving to become the representative of high-end catalysts in China's chemical industry and the pioneer of replacing imported catalysts Xunkai catalyst products include RaneCAT series Raney metal catalyst series including Raney nickel Raney copper and Raney cobalt for nitro hydrogenation and nitrile hydrogenation CuCAT series Cu-Zn Cu-Si Cu-Al series catalysts used in alcohol dehydrogenation ester hydrogenation aldehyde hydrogenation and other fields PMCAT series palladium platinum ruthenium supported on activated carbon or alumina catalysts used in hydrogenation dechlorination deep desulfurization fuel cell desulfurization and other fields SNCAT series powder supported nickel catalyst fixed bed supported nickel catalyst used in C5 resin hydrogenation C9 resin hydrogenation DCPD resin hydrogenation rosin and its resin PAO polyalphaolefin oil hydrogenation and so on The latest chemical consulting please click to follow me! Information source of this article | Environmental Protection Chemical Platform Please contact us if there is any violation or infringement Return to Sohu to see more Responsible Editor toptiontech.com

Glass Liquid Film Evaporator Stainless Steel Thin Film Evaporator Changzhou Scraper Thin Film Evaporation System

Original Title Glass Liquid Film Evaporator Stainless Steel Thin Film Evaporator Changzhou Scraper Thin Film Evaporation Product introduction Thin-film evaporation is a liquid-liquid separation method Thin-film evaporator is mainly composed of heating jacket internal rotatable scraper condenser and vacuum system Under high vacuum the feed liquid enters from the upper part of the evaporator and forms a cbd crystallization equipment downward spiral film along the inner wall of the evaporator under the action of gravity and the rotary scraper By utilizing the different boiling points of materials the distillate is discharged from the bottom into the heavy component receiver and the secondary steam is discharged from the upper part into the light component receiver through the condenser thus completing the whole separation process

Thin film evaporation is suitable for the separation of feed liquid with high visغير مجاز مي باشدity easy crystallization easy scaling suspended solids or heat sensitivity and is widely used for product pretreatment and finishing in chemical غير مجاز مي باشدmetics perfume and other industries wiped film evaporator Structural features 304/316L stainless steel material The main body of the equipment is made of 304/316L stainless steel material which ensures the stability and service life of the equipment thus achieving a lasting production rate Fully automatic operation of PTEF material sealing the sealing system of the equipment adopts PTEF material to realize the air tightness and high vacuum degree of the whole system The fully automatic operation system automatic feeding and automatic collection make the separation efficiency Scraper Short-path Distillation System Scraper short-path distillation system made of stainless steel 304/316L for high separation efficiency with short operation time Product features Made of high quality 316 and 304 stainless steel with high decarboxylation after extraction stability and long instrument time; Short-path distillation short material residence time (a few seconds to separate successfully); High vacuum degree low distillation temperature and high distillation efficiency; Can be continuously distil without interruption; A variety of models to choose from suitable for small-scale experiments pilot production or large-scale production Customizable services can provide a complete set of services; Plug and play automatic distillation simple operation; return to Sohu see more Responsible Editor toptiontech.com